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Pulmonary Metastasectomy For 29 Patients With Colorectal Carcinoma: A Single Center Experience
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Original Article
VOLUME: 49 ISSUE: 3
P: 197-205
2016

Pulmonary Metastasectomy For 29 Patients With Colorectal Carcinoma: A Single Center Experience

Acta Haematol Oncol Turc 2016;49(3):197-205
DOI: 10.5505/aot.2016.80299
Mehmet Serdar Cengizhan
İlhan Öztop
Tarık Salman
Aydın Şanlı
Olçun Ümit Ünal
1. Dokuz Eylul University, Medical Faculty, Department Of Internal Medicine, Izmir, Turkey.
2. Dokuz Eylul University, Oncology Institute, Department Of Medical Oncology,Izmir, Turkey.
3. Izmir Katip Celebi University, Medical Faculty, Department Of Medical Oncology,Izmir, Turkey.
4. Dokuz Eylul University, Medical Faculty, Department Of Chest Surgery, Izmir, Turkey.
5. Izmir Bozyaka Education and Research Hospital, Department Of Medical Oncology,Izmir, Turkey.
6.
No information available.
No information available
Received Date: 2016-05-07T17:17:03
Accepted Date: 2016-12-14T14:38:33
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Abstract

INTRODUCTION

Synchronous or metachoronous distant metastasis develops in approximately 50-60% of patients with colorectal cancer during the clinical course. Surgical resection of the hepatic and/or pulmonary metastasis of colorectal cancers significantly extends disease-free survival (DFS) and overall survival (OS) rates, and thus has been applied more broadly in recent years.

METHODS

In this study, 29 patients who were treated at the Dokuz Eylül University Medical Faculty Hospital and who had received a metastasectomy due to a lung metastasis related to colorectal cancer were evaluated. Information on the patients was obtained retrospectively.

RESULTS

Twenty-four (82.8%) patients had an isolated lung metastasis and 5 (17.2%) had both lung and liver metastasis. Resection was performed on all patients for lung metastasis, and a lung+liver metastasectomy was performed on 5 (17.2%). For the entire patient group, the median OS was 57 months (SD± 4 months), and 1, 3, and 5 year survival rates were 96%, 92% and 49%, respectively. In patients who received follow-up treatment after undergoing the metastasectomy operation and who did not have lesions, the median DFS was 31 months (SD± 3 months), and 1, 3, and 5 year DFS rates were 86.3%, 42% and 1%, respectively. In patients who received wedge resection treatment, the median OS was 58 months (SD± 5 months), and for the patients who received lobectomy treatment, the median OS was 50 months (SD± 2 months). In the evaluations made according to the resection type, median OS was 66 months (SD± 5 months) in patients who had R0 resection and 47 months (SD± 7 months) in patients who had R1 resection.

DISCUSSION AND CONCLUSION

Our results show that surgical resection, particularly an R0 resection of lung metastasis in colorectal cancer patients contributes to extended patient OS time.