Abstract

INTRODUCTION

Gastric Cancer is still causes high morbidity and mortality. So the researchers directed to research the factors affecting prognosis. In our present study, the effects of both MMP7 -181G>A promoter polymorphism and H. pylori infection on gastric cancer prognosis was investigated in gastric adenocarcinoma.

METHODS

All of the cases (n=50) and healthy controls (n=50) were unrelated individuals who were selected from the xxx hospital, Department of Surgical Oncology between October 2008 and October 2010. The study group consisted of 50 patients, including 31 males and 19 females, including 15=AA, 20=AG, 15=GG genotype. In the control group; 25=AG, 9=GG and 16=AA genotype was found.

RESULTS

G1+G2 and G3 phases were compared according to A/G polymorphism. G allele frequency of stage G3=53.8% of patients with G1+G2 phase was found 45.8%. According to this result; the frequency of G allele being considered to increase the G phase. Patients compared with H.Pylori and tumor size, in stage T1+T2 no patients had H pylori (+), in T3+T4, 65.1% of those with H pylori(+) was found (p= 0.02). This situation proved previously conducted studies that H. pylori is a negative prognostic factor for gastric cancer.

DISCUSSION AND CONCLUSION

In this study healthy volunteers population was found the frequency of A allele=%57, frequency of allele G=43%, this condition is found to be parallel with the European's G allele frequency. In our country and in Europe stomach cancer prognosis is worse than Japan because frequency of G allele is more than Japan.