EN | TR
E-ISSN: 3061-9947
Prognostic significance of mucinous colorectal carcinoma
PDF
Cite
Share
Request
Original Article
VOLUME: 53 ISSUE: 1
P: 123-129
2020

Prognostic significance of mucinous colorectal carcinoma

Acta Haematol Oncol Turc 2020;53(1):123-129
DOI: 10.5505/aot.2020.57338
Serhat Tokgöz 1
Fatma Buğdaycı Başal 2
Selim Tamam 1
1. University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital Department of General Surgery, Ankara, Turkey
2. University of Health Sciences,Ankara Dr.A.Y. Oncology Research and Training Hospital Department of Medical Oncology, Ankara, Turkey
3.
No information available.
No information available
Received Date: 2019-10-09T13:55:00
Accepted Date: 2020-04-28T11:25:49
PDF
Cite
Share
Request

Abstract

INTRODUCTION

Mucinous adenocarcinoma is a subtype of colorectal adenocarcinomas. Although it differs from non-mucinous adenocarcinomas (nMA) genetically, clinically and pathologically, the prognostic significance of mucinous adenocarcinomas (MA) is controversial. The aim of this study is to evaluate the clinicopathological features and prognostical significance of colorectal mucinous adenocarcinoma.

METHODS

The datas of 413 patients that has been operated in our clinic between January 2012 and December 2018 due to adenocarcinoma of colon were scanned. In the analyses, age, sex, location, tumour size, invasion depth, lymph node metastasis, existence of distant metastasis, operation method and degree of urgency, perineural and lymphovascular invasion, mucinous histology were investigated as prognostic factors.

RESULTS

In the mucinous group, the disease was more localized in the colon, tending to be greater than 5 cm, and the depth of invasion was greater. All patients had a 3-year overall survival rate of 74% and a 5-year overall survival rate of 63%. Survival rates were lower in the mucinous group (3-year overall survival; MA 58%, nMA 75% p = 0.01; 5-year overall survival; MA 58%, nMA 64% p = 0.01). In univariate analyzes, all variables except tumor size and gender were significantly different. In multivariable analyses, it is observed that being over 65 years, distant metastasis, perineural invasion, the urgency of the operation and mucinous histology presence were related to poor prognosis. (MA 33.9±3.4, nMA 58.1±1.7 months p: 0.006)

DISCUSSION AND CONCLUSION

Biological behaviour of MA is worse than nonmucinous adenocarcinomas. It is mandatory to develop individual therapies according to subtypes, histological and genetical features of cancers in order to increase the therapeutic success in colorectal cancers.