EN | TR
E-ISSN: 3061-9947
Predictive Factors Of Liver Metastasis After Curative Treatment For Colorectal Cancer
PDF
Cite
Share
Request
Original Article
VOLUME: 49 ISSUE: 1
P: 1-5
2016

Predictive Factors Of Liver Metastasis After Curative Treatment For Colorectal Cancer

Acta Haematol Oncol Turc 2016;49(1):1-5
DOI: 10.5505/aot.2016.25993
Cemil Hocazade
Nuriye Yıldırım
Yakup Bozkaya
Gökhan Uçar
Nurullah Zengin
1. Department Of Medical Oncology, Ankara Numune Education And Research Hospital, Ankara, Turkey
2.
No information available.
No information available
Received Date: 2015-11-13T09:56:25
Accepted Date: 2016-03-01T17:03:19
PDF
Cite
Share
Request

Abstract

INTRODUCTION

Colorectal cancer (CRC) is one of the most commonly detected cancers worldwide. Liver metastasis might develop shortly after the diagnosis of colorectal cancer. Liver metastasectomy might improve the five year survival rate to 20-40% in patient with previously treated CRC. We aimed in this study to evaluate the predictive factors to liver metastases in patients with newly diagnosed non metastatic CRC.

METHODS

Five hundred and seventeen non-metastatic colorectal patients followed at Medical Oncology Department of Ankara Numune Training and Research Hospital between January 2009 and August 2014 were evaluated retrospectively. Patients were divided in to the two subgroups. Group 1 consisted of non-metastatic and metastatic patients except liver metastases. Group 2 consisted of patients with liver metastases. Laboratuary results at the time of diagnosis were evaluated with receiver operating characteristic (ROC) Curve analysis and cut-off values were determined for lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and gama glutamil transferase (GGT) with (400 U/L, 50 ng/ml and 90 U/L, respectively).

RESULTS

There were 7 cases (%35) with high CEA levels in Group 2 and 28 (%8,7) cases in Group 1. There was a significant difference between this subgroups in univariate analysis (p<0,001). According to LDH levels, there were 5 (%33,3) liver metastases in high LDH group and 17 (%9) liver metastases in low LDH group (p=0,003). There were 5 cases (%33,3) of liver metastases in patients with high GGT and 24 cases(%9,8) in patients with low GGT (p=0,005). LDH was remained only significant factor after multiple logistic regression analysis (OR 7,8: 1,02-59,3).

DISCUSSION AND CONCLUSION

Hepatic metastases from colorectal cancer were an important predictive factor of overall survival. In our study we showed that high LDH levels at the time of diagnosis might be useful predictive factor of liver metastases. We need prospective randomized studies to determine effect of high LDH levels in colorectal cancer.