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Opioid Administration for Mucositis-related-Pain Using Patient Controlled Analgesia (PCA) Method is Associated with the Development of Early Posttransplant Complications
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Original Article
VOLUME: 56 ISSUE: 2
P: 125-135
2023

Opioid Administration for Mucositis-related-Pain Using Patient Controlled Analgesia (PCA) Method is Associated with the Development of Early Posttransplant Complications

Acta Haematol Oncol Turc 2023;56(2):125-135
DOI: 10.5505/aot.2023.87360
Kübra Haşimoğlu Gürün 1
Zeynep Arzu Yegin 2
Didem Akçalı 3
Zübeyde Nur Özkurt 2
Oktay Tertemiz 3
Ferda Can 2
Asena Dikyar 2
Suzan Berkiten 2
1. Gazi University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey
2. Gazi University Faculty of Medicine, Department of Hematology, Ankara, Turkey
3. Gazi University Faculty of Medicine, Department of Anesthesiology, Ankara, Turkey
4.
No information available.
No information available
Received Date: 2022-12-02T16:48:39
Accepted Date: 2023-08-07T09:03:08
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Abstract

INTRODUCTION

Mucositis is one of the major complications of allogeneic hematopoietic stem cell transplantation with myeloablative conditioning. Several measures have been developed to improve pain palliation and quality of life in transplant recipients. This study was performed to evaluate the association of opioid administration using patient controlled analgesia (PCA) method with early posttranplant complications.

METHODS

Medical records of 452 patients [median age: 35(15-67) years, male/female: 285/167] were retrospectively reviewed.

RESULTS

PCA was used in 157 patients (34.7%) for median 9(1-24) days. The proportion of patients who received myeloablative conditioning regimen was significantly higher in PCA+ group (p<0.001). Severe mucositis was more common in patients who required PCA administration (p<0.001). Total body irradiation (p<0.001) and methotreaxate prophylaxis (p<0.001) were more frequently used in PCA+ patients. Hypoxia, bleeding, sinusoidal obstruction syndrome, invasive fungal infections, neurotoxicity, hepatotoxicity and nephrotoxicity were significantly more common in PCA+ patients. Duration of hospitalization was significantly longer in PCA+ group (p<0.001).

DISCUSSION AND CONCLUSION

Opioid administration with PCA, which was more frequently used in patients who had myeloablative conditioning and mucositis, was found to be associated with the development of early posttransplant complications.