Microbiota is all microorganisms that share our body and microbiota ecosystem plays an important role in human health such as spplying nutrients, K vitamin, digestion, Microbiota affects many immun functions by biological molecules and change of the microbiota (disbiosis) has a critical roles development of multple diseases. Recently it has been reported that microbiota is an important part of carcinogenesis cause by immun evasion and has effect on the treatment of cancer.