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Matched comparison of p53, c-erb B2 and bcl-2 markers in breast cancer tissue and fine needle aspiration biopsy materials
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Original Article
VOLUME: 47 ISSUE: 3
P: 9-15
2014

Matched comparison of p53, c-erb B2 and bcl-2 markers in breast cancer tissue and fine needle aspiration biopsy materials

Acta Haematol Oncol Turc 2014;47(3):9-15
DOI: 10.5505/aot.2014.48568
Esin Cengiz Boduroğlu
Sultan Çiğdem Irkkan
Tulu Ayata Kebat
1. Dr. A. Y. Ankara Oncology Training And Research Hospital, Department Of Pathology, Ankara, Turkey
2.
No information available.
No information available
Received Date: 2014-08-28T12:23:02
Accepted Date: 2015-02-27T09:37:35
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Abstract

OBJECTIVE

Fine needle aspiration biopsy in breast cancer is accepted to be an appropriate alternative to surgical biopsy both for diagnosis and to define some prognostic parameters. In this study comparison of p53, bcl-2, c-erb B2 immunoreactivities on both fine needle aspiration biopsy samples and tissue sections from 100 consecutive mastectomy specimen with breast cancer was performed.

METHODS

Frozen samples of tissue were used in the study in order to eliminate the effects of the tissue processing.

RESULTS

The adequacy of samples was 98.67% for the tissue sampling and 99.00% for the cytologic materials. There were statistically significant relationship between tissue and cytologic material for each of the three markers (p‹0.05). The sensitivity of p53 in cytologic material was quite low (50%) but sensitivity was high (92.3%). The sensitivity and the specifity for both bcl-2 and c-erb B2 were high (sensitivity 89.2%, 84.1% and specifity 92.5%, 89.6% respectively).

CONCLUSION

Fine needle aspiration biopsy material could be used safely to determine p53, bcl-2, c-erb B2 in breast cancer, but it has to be kept in mind that the p53 specifity is quite low and p53 staining in cytologic material could lead to false negative results.