Abstract

A fifty three year old male patient vvas diagnosed as high grade malignant lymphoma with splenectomy. Lymphadenopathy with various sizes were seen in abdomen computerized tomography (CT). Lytic lesions were seen at pelvic bones. Bone mar-row aspiration and biopsy vvas normal. Six cycles of CNOP chemotherapy were given. Abdomen lymphadenopathies disappe-ared after chemotherapy, but lytic lesions were stili observed in thoracall-omber-pelvic bones with magnetic resonance imaging (MRI). Three cycles of MİNE chemotherapy vvas given. 20-25% regression in lytic lesions were seen. CT vvas taken because of headache and vertigo. There vvas stili ınvolvement in cranial MRI vvhich vvas taken after a month. Fourth cycle of MİNE vvas given. Repeated bone marrovv aspiration and biopsy vvas normal. Because of backpain, losing of povver and sensation, thoracal lomber MRI vvas repeated. Spinal involvements were seen. Lomber radiotherapy vvas started. Remission could not be achieved and the patient detoriated rapidly. The only bone metastasis vvithout bone marrovv Involvement is seen rarely in lymphomas and its clinical course is bad.