Incidental appendix neuroendocrine tumor and current treatment approach in patients with acute appendicitis
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Original Article
VOLUME: 51 ISSUE: 1
P: 17 - 20
2018

Incidental appendix neuroendocrine tumor and current treatment approach in patients with acute appendicitis

Acta Haematol Oncol Turc 2018;51(1):17-20
1. Ministry of Health Recep Tayyip Erdogan University Training And Research Hospital, Rize
2.
No information available.
No information available
Received Date: 2017-10-10T15:32:12
Accepted Date: 2018-04-23T16:28:10
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Abstract

INTRODUCTION

The appendix is one of the common sites of neuroendocrine tumor (NET) which was formerly called as carcinoid tumor. It is mostly asymptomatic and incidentally detected after appendectomy or other abdominal operations. In this study, pathology results of patients which underwent operation for acute appendicitis and diagnosed as NET were evaluated.

METHODS

The files and pathology results of 586 patients which were operated for acute apandicitis in Recep Tayyip Erdoğan University Educational and Research Hospital between January 2015 and December 2016 were evalıuated retrospectively. The age, gender, histopathological diagnosis of the patients and the macroscopic tumor findings, tumor site, tumor size, surgical margin, Ki 67 index, mitotic index and subsequent treatments of the cases that was reported as appendicitis were evaluated.

RESULTS

365 of the patients were male and 228 female. The mean age was 28.2 (1-88). Well differentiated NET was detected in three patients (0.5%). Acute appendicitis was not detected in the specimens of these three patients. The ages of the patients were 15, 35 and 48 years. Tumor sizes were 0.4, 0.6 and 1.2 cm. In all cases, the tumor was on distal site. The surgical margin was negative in two patients and positive in one patient. Ki 67 proliferation index was < 2% and mitotic index <2/10 Hpf in all three patients. Right hemicolectomy was performed in the first month after surgery in the patient with positive surgical margin. Two other patients were offered follow-up and discharged.

DISCUSSION AND CONCLUSION

It is difficult to diagnose appendix NET before histopathological examination. Life expectancy is well in these patients. However the possibility of development of synchronous or metachronous colorectal malignancies should not be forgotten.

Keywords:
Appendix neuroendocrine tumor, appendectomy, incidental