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E-ISSN: 3061-9947
Impact of Baseline Neutrophil-to-Lymphocyte Ratio on Outcomes of GlioblastomaMultiforme Patients Treated with Standart Concurrent Chemoradiotherapy
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Original Article
VOLUME: 54 ISSUE: 3
P: 298-307
2021

Impact of Baseline Neutrophil-to-Lymphocyte Ratio on Outcomes of GlioblastomaMultiforme Patients Treated with Standart Concurrent Chemoradiotherapy

Acta Haematol Oncol Turc 2021;54(3):298-307
DOI: 10.5505/aot.2021.81598
Berna Akkuş Yıldırım 1
Ayse Kotek Sedef 1
Erkan Topkan 1
Ahmet Taner Sümbül 2
1. Department of Radiation Oncology, Baskent University Medical School, Adana, Turkey
2. Department of Medical Oncology, Baskent University Medical School, Adana, Turkey
3.
No information available.
No information available
Received Date: 2021-05-28T14:04:10
Accepted Date: 2021-12-01T07:06:02
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Abstract

INTRODUCTION

Glioblastoma multiforme (GBM) is the most common and miserable prognosis primary brain tumor in adults. Previously neutrophil-to-lymphocyte ratio (NLR), a marker of systemic inflammation has been demonstrated to have both strong predictive and prognostic value in different cancer types, which has rarely been addressed in GBM patients.The aim of this retrospective cohort study was to evaluatethe prognostic value of pretreatment NLR on survival outcomes of GBM patients who were underwent surgery/biopsy followed by definitive chemo-radiotherapy (CRT) and accessibility of a certain cut-off worth for NLR

METHODS

This study was a hospital-based retrospective observational case-series study. This study was designed to identify 144 GBM patients with full pretreatment and treatment records that underwent surgery/biopsy followed by CRT from January 2007 to December 2011 in our clinics. Age, symptoms, laboratory results and treatment modalities of patients were recorded.

RESULTS

The median follow-up time for the whole population was 15.1 (range1.8-49.9) months, with 95 patients (84.8%) being death at the time of this analysis. NLR cut-off values of 4.3 (AUC: 78.4;95% CI: 64.8-92)for overall- (OS) and 4.1 (AUC: 72.7; 95% CI: 61-84.1)forlocal recurrence-free survival (LRFS) were identified, respectively, by using receiver operating curve analysis. Low NLR was associated with significantly longermedian OS(23.2 vs. 12.7 months p=0.001), and LRFS (13.9vs 9.6 months; p<0.001) as well as longer median both of which retained its independent significant associationwith survival outcomes in the multivariate analysis (p<0.001 for each).

DISCUSSION AND CONCLUSION

In conclusion, pre-treatment Low-NLR values associate with significantly longer OS and LRFS than those presenting with high-NLR. These findings suggest a novel strong and independent prognostic value for baseline NLR which is cheap, reproducible and easy to measure in routine clinical practice.ce.