Abstract

INTRODUCTION

The aim of the study was to retrospectively evaluate the prognostic factors affecting the disease-free survival and overall survival in gastric cancer patients after the operation.

METHODS

In the study, the medical records of 194 patients who received adjuvant therapy with the diagnosis of gastric cancer in our center between January 2014 and December 2018 were retrospectively analyzed from the system notes and patient files. Gastric cancer patients aged 18 years or older who underwent operation were included in the study group. Secondary malignancy, peritoneal involvement or distant metastasis were not included in the study group. Log-Rank test was used to compare survival times between groups, and Cox Regression analysis was used to determine prognostic factors for survival.

RESULTS

The median age of 194 patients (66.0% male, 34.0% female) was 60 (26-85). In univariate analysis; poor performance score, advanced Tumor (T) stage, advanced Node (N) stage, advanced Tumor, Node, Metastasis (TNM) stage, and increased metastatic lymph node ratio were found to be poor prognostic factors for disease-free survival and overall survival. Lymphovascular invasion was found only as a poor prognostic factor for disease-free survival. In Cox regression analysis, advanced T stage and advanced TNM stage for overall survival and advanced T stage for disease-free survival were determined as independent poor prognostic factors.

DISCUSSION AND CONCLUSION

According to the results obtained, it was shown that advanced T stage and TNM stage may be poor prognostic factors in terms of overall survival in patients with operated gastric cancer and also advanced T stage negatively affected disease-free survival.