Effect of FcγRIIa and FcγRIIIa Gene Polymorphism on Treatment Response and Overall Survival in Diffuse Large B Cell Lymphoma
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Original Article
VOLUME: 51 ISSUE: 1
P: 26 - 30
2018

Effect of FcγRIIa and FcγRIIIa Gene Polymorphism on Treatment Response and Overall Survival in Diffuse Large B Cell Lymphoma

Acta Haematol Oncol Turc 2018;51(1):26-30
1. Health Sciences University Bozyaka Training and Research Hospital Division of Hematology Bozyaka/İzmir
2. Dicle University Medical School Department of Biochemistry Diyarbakır
3.
No information available.
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Received Date: 2017-10-12T14:24:25
Accepted Date: 2018-04-23T16:31:02
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Abstract

INTRODUCTION

A study was planned to investigate the response of diffuse large B-cell lymphomas with FcγRIIa and FcγRIIIa, gene polymorphism to R-CHOP therapy.

METHODS

Total 90 patients (47 female and 43 male) with CD20 + diffuse large B-cell lymphoma diagnosed with FcγRIIa and FcγRIIIa gene polymorphism by qPCR technique. The response was assessed by treatment with six cycles of R-CHOP treatment and the overall survival of cases diagnosed with polymorphism was calculated.

RESULTS

There was no statistically significant difference in response to treatment between FcγRIIa and FcγRIIIa gene polymorphism and other cases.

DISCUSSION AND CONCLUSION

Diffuse large B-cell lymphoma with FcγRIIa and FcγRIIIa gene polymorphism has no effect on to overall survival as a result of treatment response.

Keywords:
diffuse large B cell lymphoma, response to treatment, Fcγ, RIIa, FcγRIIIa, gene polymorphism