Abstract
INTRODUCTION
A study was planned to investigate the response of diffuse large B-cell lymphomas with FcγRIIa and FcγRIIIa, gene polymorphism to R-CHOP therapy.
METHODS
Total 90 patients (47 female and 43 male) with CD20 + diffuse large B-cell lymphoma diagnosed with FcγRIIa and FcγRIIIa gene polymorphism by qPCR technique. The response was assessed by treatment with six cycles of R-CHOP treatment and the overall survival of cases diagnosed with polymorphism was calculated.
RESULTS
There was no statistically significant difference in response to treatment between FcγRIIa and FcγRIIIa gene polymorphism and other cases.
DISCUSSION AND CONCLUSION
Diffuse large B-cell lymphoma with FcγRIIa and FcγRIIIa gene polymorphism has no effect on to overall survival as a result of treatment response.