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Early Bilirubin Levels Following Percutaneous Biliary Drainage and Stenting Performed for Malignant Biliary Obstruction
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Original Article
VOLUME: 50 ISSUE: 3
P: 201-206
2017

Early Bilirubin Levels Following Percutaneous Biliary Drainage and Stenting Performed for Malignant Biliary Obstruction

Acta Haematol Oncol Turc 2017;50(3):201-206
DOI: 10.5505/aot.2017.82905
Mehmet Burak Çildağ
Ömer Faruk Kutsi Köseoğlu
1. Adnan Menderes University, Medicine Faculty, Department of Radiology
2.
No information available.
No information available
Received Date: 2017-02-01T21:20:08
Accepted Date: 2017-12-19T11:27:35
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Abstract

INTRODUCTION

Secondary bile duct obstruction and bilirubin elevation may be observed in malignancies. Bilirubin levels below a specified amount are required in order to administer chemotherapy. Percutaneous biliary drainage (PBD) and stenting are performed for palliative treatment of bile duct obstructions. Bilirubin levels decrease after percutaneous biliary drainage. In this study, we aimed to demonstrate the postoperative short-term change in bilirubin levels in cases whose bilirubin levels decreased below 2 mg/dL within 2 months, regardless of predrainage level.

METHODS

The amounts of bilirubin on the day before percutaneous biliary drainage, and on post percutaneous biliary drainage days 1, 7 and 15 were recorded for technically successful cases who had obstructive jaundice due to malignant causes on dates January 2014-December 2016 for cases whose bilirubin levels decreased to <2 mg/dL within 2 months after the procedure.The type and degree of tumor leading to bile obstruction was examined in all patients.

RESULTS

In study period, 40 patients who met the criteria were found. A decrease by 17.7% on day 1, 38.4% on day 7 and 59.4% on day 15 was observed in the mean bilirubin amount compared to the pre PBD mean bilirubin level.The amount of bilirubin decrease was only correlated with predrainage bilirubin level. No correlation was found between the amount of bilirubin decrease and the degree of obstruction, the presence or absence of malignancy and liver metastasis that constitutes the etiology of obstruction.

DISCUSSION AND CONCLUSION

Percutaneous biliary drainage and stenting is considered as palliative treatment of bile duct obstruction due to malignant causes and purposes of the procedure include decreasing bilirubin levels to enable chemotherapy administration for the patient. For cases whose bilirubin levels had decreased to <2 mg/dL at 2 months after percutaneous biliary drainage and stenting, this study demonstrated the mean decrease in bilirubin levels on days 1, 7 and 15 as 17.7%, 38.4% and 59.4%, respectively.