Analysis of BRAF V600E Mutation in Gastrointestinal Malignant Melanomas
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Original Article
VOLUME: 51 ISSUE: 1
P: 61 - 67
2018

Analysis of BRAF V600E Mutation in Gastrointestinal Malignant Melanomas

Acta Haematol Oncol Turc 2018;51(1):61-67
1. Department of Pathology, Ankara Yıldırım Beyazıt University, Atatürk Education and Research Hospital, Ankara, Turkey
2.
No information available.
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Received Date: 2017-10-05T11:47:06
Accepted Date: 2018-04-23T16:40:08
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Abstract

INTRODUCTION

We aimed to investigate BRAF V600E mutation in gastrointestinal mucosal melanomas and patients’ clinical outcomes.

METHODS

The melanomas which were diagnosed at Ankara Yıldırım Beyazıt University/ Atatürk Education and Research Hospital between 2006 and 2015 were retrospectively screened for mucosal melanomas. Gastrointestinal malignant melanomas were obtained from these cases. BRAF V600E mutation analysis is performed to a total of 6 gastrointestinal melanoma cases by real time PCR method. In addition clinical characteristics of these cases have beeen reviewed.

RESULTS

Six of the 14 patients with mucosal melanoma were gastrointestinal. There were cases of rectum and 2 cases of small bowel, and patients were between 54- 84 years. BRAF V600E mutation was detected in one of the small bowel localized case with omentum metastasis.

DISCUSSION AND CONCLUSION

The only case with BRAF V600E mutation was multifocal therefore mucosal metastatis is considered in this case. Primary cutaneous and ocular melanomas can frequently metastasize to the gastrointestinal tract. However, it may not always be possible to identify the primary tumor. Primary gastrointestinal melanomas are very rare and genetically different from cutanous melanomas.

Keywords:
Gastrointestinal, melanoma, BRAF V600E mutation