Abstract
INTRODUCTION
We evaluated the effect of advanced age on oncological outcomes after radical prostatectomy (RP) in non-metastatic prostate cancer (PCa) patients.
METHODS
Totally 593 patients’ data was retrospectively evaluated. All patients were divided into two groups: <70 (n=454) and ≥70 (n=139) years of age. Demographic, pathological and post-operative oncological outcomes were compared between these two groups. The primary endpoint was to evaluate the effect of advance age on biochemical recurrence free survival (BRFS) and overall survival (OS). Logistic regression analysis was performed to predict BRFS and OS. Kaplan-Meier pilots are provided for BRFS and OS up to ten years.
RESULTS
The OS rates were 85.2% vs. 64%, and 67.2% vs. 23.7% in comparing the younger group to the older group at the 5th, and 10th year of follow-ups, respectively (p < 0.001 for the both comparisons). The BRFS rates were 83.9% vs. 80.9%, and 85.2% vs. 39.4% when comparing the younger group to the older group at the 5th, and 10th year of follow-ups, respectively (p = 0.29, and p < 0.001, respectively). Factors of a Gleason score higher than 7 on radical prostatectomy, seminal vesicle invasion, and advanced stage were found to be significant factors affecting BRFS, in univariate analysis. In the multivariate analysis, it denoted advanced pathological stage (T3) and high Gleason score (≥8) as prognostic factors affecting BRFS. OS was found to be worse in the older patients’ group and age was found as a primary factor in prediction of OS.
DISCUSSION AND CONCLUSION
There is no relationship between advanced age and oncological outcomes after RP in non-metastatic PCa patients.