An Elderly Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Case Developed After 3 years of Post-chemotherapy
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Case report

An Elderly Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Case Developed After 3 years of Post-chemotherapy

Acta Haematol Oncol Turc 2019;52(3):485-487 DOI: 10.5505/aot.2019.68736
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Abstract

Introduction: Hematopoietic malignancies may also develop in relation to treatment. Here, we report a case of acute lymphoblastic leukemia that developed in a patient who received chemotherapy and radiotherapy due to gastric cancer about 3 years later. Case: A patient with known gastric adenocarcinoma received FUFA (5 Fluoro-uracil / leucoverin) weekly for simultaneous radiotherapy after subtotal gasrectomy. Leukocytosis was detected approximately 3 years later and B cell acute lymphoblastic leukemia (B-ALL) was diagnosed. The Philedelphia chromosome t (9; 22) was positive with RT PCR. The patient was given 12 cycles of POMP maintenance + imatinib 600 mg. The patient who had relapse was started on dasatinib treatment. Discussion: It should be kept in mind that patients with previous chemotherapy may develop ALL instead of MDS and AML.

Keywords: acute lymphoblastic leukemia, secondary, chemotherapy, radiotherapy