Abstract
INTRODUCTION
Thirty - four patients with osteolytic bone metastasis were included in the study to evaluate bone mineral density and pain response in terms of treatment response after two different 10fr × 3 Gy and 5fr × 4 Gy dose-fraction schemes.
METHODS
18 of the patients have taken 10fr×3 Gy and 16 of them have taken 5fr×4 Gy radiotherapy treatment. Having taken the patient’s self evaluation as basis in the pain tratment efficiency; the pain intensity is evaluated with respect to VAS pain scale from 1st day to 15 day daily, and finally at 45th day. BMD is measured with DXA (dual energy X-ray absorptiometry) two times; before treatment and after 6 months.
RESULTS
Even though there is a significant statistical decrease in the two different dose-fraction treatment with respect to time, no difference is found between the two groups (p=0.387). It is evaluated that BMD has a 23.4% increase in the 10fr×3Gy dose-fraction treatment group (p<0.0001); where it has a 19.9% increase in the 5fr×4 Gy dose-fraction treatment group (p<0.0001). There is not a significant difference with respect to treatment response between the two dose-fraction treatment groups.
DISCUSSION AND CONCLUSION
No predominance is found with respect to pain response and BMD between 10fr×3 Gy and 5fr×4 Gy dose-fraction treatment groups. Bone mineral density measurements locally indicates radiotherapy response more precisely.
Keywords: Bone mineral densitometry, bone metastases, palliative radiotherapy, fractionation, pain
