Abstract
INTRODUCTION
Lung cancers widespread throughout the world. Previously known prognostic factors in lung cancers are inadequate in reflecting a change in prognosis and clinical course of the tumour. The aim of this study was to determine the effect on prognosis of tumour DNA ploidy type in are neoplasms with high mortality rates that are extremely patients operated on for non small cell lung cancer.
METHODS
A total of 35 patients were operated on because of non small cell lung cancer. Using flow cytometric examination of fresh tumour tissue, the proliferation activity (S phase) was determined together with tumour DNA ploidy type. These data were compared with the TNM grade, the histopathological type and the last status of patients within the follow-up period.
RESULTS
As a result of DNA ploidy analysis, aneuploidy was determined in 16 (45.8%) patients and diploidy in 19 (54.2%). When the ploidy type and S phase were compared with histopathological type, TNM grade and last clinical status, recurrence and metastasis were observed at a significantly higher rate in cases with anaploidy DNA and/or high S phase (p<0.05)
DISCUSSION AND CONCLUSION
Tumour DNA ploidy type and S phase can be evaluated as effective prognostic factors reflecting the biological behaviour of the tumour in non small cell lung cancers.
Keywords: DNA ploidy, Lung Cancer, flow cytometry
