Abstract
INTRODUCTION
We aimed to evaluate the clinicopathological characteristics of patients with stage 1 granulosa cell ovarian carcinoma (GCOC).
METHODS
Between July 2006 – December 2015, the clinical and pathological parameters, treatment features and long term follow up outcomes of 15 patients with stage 1 GCOC were evaluated retrospectively.
RESULTS
: Median age was 52 (24-71).According to FIGO staging system, 9 patients had stage 1A disease and 6 patientshad stage IC GCOC. Half of (53.3%) of the patients presented with uterine bleeding (53.3%) and left over (73.3%) was the most common localization. Ten patients had abdominal hysterectomy-bilateral salphingoopherectomy-pelvic paraaortic lymph node dissection-omentectomy and whereas 3 patients had total abdominal hysterectomy-bilateral salphingoopherectomy and 2 patients had fertility sparing surgery as a surgical procedure. 3 patients had perineural invasion, 2 patients had lymphovascular invasion.Histopathological evaluation of endometrium revealed simple hyperplasia without atypia in 6 patients. As adjuvant setting, 7 patients received 3 cycles of chemotherapy [bleomycin +etoposid+ cisplatin (BEP)]. Median follow up was 77.9 months (4.1 max=18.5 month) and median overall survival was 77.9 ay (95% CI, 39.6-116.3). None of the patients relapsed durring follow-up.
DISCUSSION AND CONCLUSION
Over granulosa cell carcinoma is rare. Randomized prospective clinical trials are needed to find out the high risk group for adjuvant chemotherapy.
Keywords: Ovarian granulosa cell tumors, hysterectomy, salpingo-oophorectomy, adjuvant chemotherapy
