The role of Nicotiana rustica (Maras powder) in the etiology of bladder carcinoma

INTRODUCTION: It is accepted that smoking increases the risk of bladder cancer by 2-4 times however studies evaluating the relationship between the use of different tobacco types and bladder carcinoma are limited. In this study, the effect of Nicotiana Rustica, known as Maraþ powder, on bladder cancer was investigated.

METHODS: The data of 98 patients who underwent transurethral bladder tumor (TUR-M) resection due to bladder tumor in our clinic between 2014-2019 were evaluated retrospectively and 41 cases were found to be in accordance with the study criteria. Cases were divided into three groups: regular smoking, Maras powder and none. In the light of the data obtained, a comparison was made between the groups.
RESULTS: Of the patients diagnosed with bladder carcinoma, 71% were male and 29% were female. The mean age of the patients was 63 years (51-79 years). When all cases were grouped according to the tobacco used; group 1 consisted only of cases using cigarette, group 2 using only smokeless tobacco, and group 3 consisted of cases using no tobacco products; 51% of these patients smoked and 15% used Maras powder. It was seen that 5 of the 6 patients who used Maras powder used more than 5 herbs per day and all of these cases had T1 tumors; the only one case with Ta pathology which using less than 5 herbs.

DISCUSSION AND CONCLUSION: The relationship between the use of Maras powder and bladder cancer remained poorly significant compared to the relationship between smoking and bladder cancer. However, it was found to be higher than non-tobacco_

Mesane kanserinde Nicotiana rustica (Maraþ otu) ‘nýn etyolojideki rolü

GÝRÝÞ ve AMAÇ: Sigara kullanýmý mesane kanseri riskini 2-4 kat kadar artýrmakla birlikte farklý tütün tipleri ile ilgili bu etki tam olarak kanýtlanamamýþtýr. Bu çalýþmada halk arasýnda “Maraþ otu” olarak bilinen Nicotiana Rustica’nýn mesane kanseri üzerindeki etkisi araþtýrýldý.


YÖNTEM ve GEREÇLER: Kliniðimizde 2014-2019 yýllarý arasýnda mesane tümörü nedeniyle transüretral mesane tümörü (TUR-M) rezeksiyonu gerçekleþtirdiðimiz 98 olgunun verileri retrospektif olarak incelenerek 41 olgu çalýþma kriterlerine uygun bulundu. Olgular düzenli sigara kullanýmý, Maraþ otu kullanýmý ve hiçbirini kullanmayan olarak 3 ayrý gruba ayrýldý. Elde edilen veriler ýþýðýnda gruplar arasý karþýlaþtýrma yapýldý.
BULGULAR: Çalýþmaya uygun bulunan 41 olgunun 29’u (%71) erkek iken 12 tanesi (%29) kadýn idi. Olgularýn yaþ ortalamasý 63 yýl (51-79 yýl) þeklinde hesaplandý. Tüm olgular kullanýlan tütüne göre gruplandýrýldýðýnda; grup 1 sadece sigara kullanan olgular, grup 2 sadece maraþ otu kullanan olgular ve grup 3 ise hiçbir tütün mamülü kullanmayan olgulardan oluþmaktaydý. Olgularýn %51’inde sigara kullaným öyküsü mevcut iken; %15’inde maraþ otu kullanýmý bulunmaktaydý. Maraþ otu kullanan 6 olgunun 5 tanesi günde 5 ten fazla ot kullanmakta iken bunlarýn tümünde T1 tümör izlenmiþ 5 ten az kullanýmý olan tek olgu ise Ta patolojisine sahiptir.
TARTIÞMA ve SONUÇ: Maraþ otu kullanýmý ile mesane kanseri arasýnda iliþki sigara ile mesane kanseri arasýndaki iliþkiye göre zayýf anlamlý kalmýþtýr. Ancak hiçbir tütün ürünü kullanmayan gruba göre anlamlý derecede yüksek izlendi.