Effect of hyponatremia on muscle mass and interdialytic weight gain in haemodialysis patients

INTRODUCTION: Objective:
We evaluated the relationship between the pre-dialytic serum sodium value and malnutrition, the parameters of evaluating the muscular function, muscular mass or interdialytic weight gain.

METHODS: Material and Method:
150 haemodialysis patients were included in the study planned to be cross-sectional. In the evaluation; malnutrition-inflammation score, handgrip strength, mid arm circumference, triceps skinfold, mid arm muscle circumference, and bioelectrical-impedance analysis (fat percent, fat free mass, basal metabolism rate, body mass index, total body water) were considered and examined. The six-month average of the pre-dialytic serum sodium value, which is considered monthly, was taken. The patients under the average value of 136.84 mEq/L pre-dialytic serum sodium value were included in the Group 1 and those above it were included in the Group 2. Serum albumin, C-reactive protein and the other monthly routine laboratory examinations were taken from the patient’s follow-up file. Interdialytic weight gain was calculated by extracting the patient’s post-dialysis weight from the patient’s pre-dialytic weight.

RESULTS: Results:
The only significant difference between the two groups concordant according to the age and sex was interdialytic weight gain (p < 0.001). In the analysis, there was a significant relationship (p < 0.001) and inverse correlation (r= -0.311, p < 0.001) between pre-dialytic serum sodium value and interdialytic weight gain.

DISCUSSION AND CONCLUSION: Conclusion:
No relationship was found between the pre-dialytic serum sodium value of the haemodialysis patients and inflammation, malnutrition and anthropometric measurements. There was a negative correlation between the pre-dialytic serum sodium value and interdialytic weight gain, and it was statistically significant.

Hemodiyaliz hastalarýnda hiponatreminin kas kitlesine ve interdiyalitik kilo alýmýna etkisi

GÝRÝÞ ve AMAÇ: Amaç:
Diyaliz öncesi serum sodyum deðeri ile malnutrisyon, kas kitlesi, kas fonksiyonu deðerlendirme parametreleri ve interdiyalitik kilo alýmý arasýndaki iliþki deðerlendirildi.

YÖNTEM ve GEREÇLER: Gereç ve Yöntem:
Kesitsel planlanan çalýþmaya 150 hemodiyaliz hastasý dahil edildi. Deðerlendirmede: malnutrisyon inflamasyon skoru, el kavrama kuvveti, orta üst-kol çevresi, triseps cilt kalýnlýðý; orta üst-kol kas çevresi, biyoelektiriksel impedans analizi (Yað yüzdesi, yaðsýz vücut kitlesi, bazal metabolizma hýzý, vücut kitle indeksi, toplam vücut suyu) bakýldý. Aylýk bakýlan diyaliz giriþ SNa’nin altý aylýk ortalamasý alýndý. Hastalar 136.84 mEq/L olan ortalama serum sodyum deðerinin altýnda: Grup 1 ve üzerinde Grup 2’yi oluþturdu. Serum albümin, C reaktif protein ve diðer aylýk rütin laboratuvar tetkikleri hasta dosyasýndan alýndý. Ýnterdiyalitik kilo alýmý: hastanýn diyaliz öncesi kilosundan, diyaliz sonrasý kilosu çýkarýlarak hesaplandý.

BULGULAR: Bulgular:
Yaþ ve cinsiyet uyumlu iki grup arasýndaki tek anlamlý fark interdiyalitik kilo alýmýydý (p < 0.001). Analizde serum sodyum deðeri ile interdiyalitik kilo alýmý arasýnda anlamlý iliþki (p < 0.001) ve ters orantý vardý (r= -0.311, p < 0.001).

TARTIÞMA ve SONUÇ: Sonuç:
Hemodiyaliz hastalarýnda giriþ serum sodyum deðeri ile inflamasyon, malnutrisyon, ve antropometrik ölçümlerimiz arasýnda iliþki bulunamadý. Hemodiyaliz giriþ serum sodyum deðeri ve interdiyalitik kilo alýmý arasýnda negatif korelasyon vardýr ve istatistiksel anlamlýdýr.