ATYPICAL PRESENTATION IN LANGERHANS CELL HISTIOCYTOSIS: Hearing Loss, Diabetes Insipidus, & Extensive Cutaneous Lesions with Nail Distrophy

Hocazade, Cemil; Do�an, Mutlu; Yorulmaz, Ahu; G�re��i, Servet; C�l�z, Deniz; Tuna, Elvan Evrim; Zengin, Nurullah

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ATYPICAL PRESENTATION IN LANGERHANS CELL HISTIOCYTOSIS: Hearing Loss, Diabetes Insipidus, & Extensive Cutaneous Lesions with Nail Distrophy [Acta Oncol Tur.]

Acta Oncol Tur.. 2017; 50(1): 76-80 | DOI: 10.5505/aot.2017.70299

ATYPICAL PRESENTATION IN LANGERHANS CELL HISTIOCYTOSIS: Hearing Loss, Diabetes Insipidus, & Extensive Cutaneous Lesions with Nail Distrophy

Cemil Hocazade¹, Mutlu Do�an¹, Ahu Yorulmaz², Servet G�re��i³, Deniz C�l�z⁴, Elvan Evrim Tuna⁵, Nurullah Zengin¹
¹ankara numune research and treatment hospital, dept of medical oncology
²Ankara Numune Training and Research Hospital, Dept of Dermatology
³Ankara Numune Training and Research Hospital, Dept of Pathology
⁴Ankara Numune Training and Research Hospital, Dept of Radiology
⁵Ankara Numune Training and Research Hospital, Dept of Otorhinolaryngology

Langerhans cell histiocytosis (LCH) is a clonal proliferative lymphohistiocytic disorder with mainly CD-1a positive staining. It has a wide spectrum of unifocal or multifocal mono or multisystemic disease. Rare symptoms like diabetes insipidus, hearing loss or nail distrophy might also occur according to the involved sites. In here, two cases of LCH with atypical presentation are reported with review of the literature.

Keywords: Langerhans cell histiocytosis, diabetes insipidus, hearing loss, nail distrophy

LANGERHANS H�CREL� H�ST�OS�TOZDA AT�P�K PRESENTASYON: ��itme Kayb�, Diabet �nsipit & T�rnak Distrfisi ile Beraber Geni� Kutan�z Lezyonlar

Cemil Hocazade¹, Mutlu Do�an¹, Ahu Yorulmaz², Servet G�re��i³, Deniz C�l�z⁴, Elvan Evrim Tuna⁵, Nurullah Zengin¹
¹ankara numune e�itim ve ara�t�rma hastanesi, medikal onkoloji
²ankara numune e�itim ve ara�t�rma hastanesi, dermatoloji
³ankara numune e�itim ve ara�t�rma hastanesi, patoloji
⁴ankara numune e�itim ve ara�t�rma hastanesi, radyoloji
⁵ankara numune e�itim ve ara�t�rma hastanesi, kulak burun bo�az

Langerhans h�creli histiositoz (LCH) CD-1a boyanmas� g�steren klonal proliferatif lenfohistiositik bir hastal�kt�r. Hastal�k unifokal veya multifokal tek bir sitemi veya bir�ok sitemi tutacak �ekilde geni� bir klinik seyir g�sterebilir. Tutulan alana g�re diabetes insipitus, i�itme kayb� veya t�rnak de�i�iklikleri olu�abilir. Burada atipik presentasyon g�steren iki vakay� litaret�r derlemesi ile beraber sunduk.

Anahtar Kelimeler: Langerhans h�creli histiositoz, diabetes insipitus, i�itme kayb�, t�rnak distrofisi

Cemil Hocazade, Mutlu Do�an, Ahu Yorulmaz, Servet G�re��i, Deniz C�l�z, Elvan Evrim Tuna, Nurullah Zengin. ATYPICAL PRESENTATION IN LANGERHANS CELL HISTIOCYTOSIS: Hearing Loss, Diabetes Insipidus, & Extensive Cutaneous Lesions with Nail Distrophy. Acta Oncol Tur.. 2017; 50(1): 76-80

Corresponding Author: Cemil Hocazade, T�rkiye
Manuscript Language: English

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ATYPICAL PRESENTATION IN LANGERHANS CELL HISTIOCYTOSIS: Hearing Loss, Diabetes Insipidus, & Extensive Cutaneous Lesions with Nail Distrophy

LANGERHANS H�CREL� H�ST�OS�TOZDA AT�P�K PRESENTASYON: ��itme Kayb�, Diabet �nsipit & T�rnak Distrfisi ile Beraber Geni� Kutan�z Lezyonlar