Sinusoidal Obstruction Syndrome during oxaliplatin based chemotherapy treatment.

Oxaliplatin is a commonly used chemotherapeutic agent in our oncology daily practice.Neurotoxicity is the most common side effect associated with oxaliplatin therapy.Rarely, oxaliplatin therapy can cause veno-occlusive disease in the liver sinusoids, leading to obstruction and portal hypertension. Weight gain, right upper quadrant pain, ascites, hepatic insufficiency, liver failure can be seen in patients. We presented a clinical course of venoocclusive disease, which developed in third stage colonic cancer, treated with capecitabine and oxaliplatin as adjuvant treatment.

Oksaliplatin bazlý kemoterapi tedavisi sýrasýnda geliþen Sinuzoidal Obstrüksiyon Sendromu

Oksaliplatin onkolojide günlük pratiðimizde sýk kullanýlan kemoterapötik bir ajandýr. Oksaliplatin tedavisi ile iliþkili yan etki olarak en sýk nörotoksisite görülmektedir. Nadir olarak oksaliplatin tedavisi karaciðer sinuzoidlerinde venookluziv hastalýða yol açarak obstruksiyona, portal hipertansiyona sebep olabilmektedir. Hastalarda kilo artýþý, sað üst kadran aðrýsý, karýnda asit, hepatik ensafolapti, karaciðer yetmezliði görülebilmektedir. Biz 3. evre kolon kanseri saptanan, adjuvan tedavi olarak kapesitabin ve oksaliplatin tedavisi alan hastamýzda geliþen venookluziv hastalýk bulgularýný, klinik seyrini sunduk.