Clinicopathological Analysis of Patients with Malign Melanoma

INTRODUCTION: Our aim in this study is to analyse patients with malign melanoma clinicopathologically.
METHODS: In this study, 166 malign melanoma patients that followed by Dokuz Eylul University Hospital Medical Oncology Clinic in years between 1996 and 2011 were evaluated retrospectively.
RESULTS: 87 of patients is male, 79 is female. The median age is 52 (21-81). The most common site for malign melanoma is extremity; head, neck and body are less commonly involved. There is no statistically significant difference between primary tumor site and breslow thickness (p=0.109). Breslow thickness and survival are related statistically significant. Average survival time for Breslow thickness between 0 and 2mm is 125,6 months (99-151), 2 and 4 mm is 121,2 months (92-151) and over 4mm is 89 months (68-111) and difference between groups are statistically significant (p=0,012). 1 year survival rate for all patients is 96%, 2 year survival rate is 92.1% and 5 year survival rate is 82.7%. Average survival time is detected as 89,74±6,9 months. Mean survival time for female patients is 108.8 months, 72.9 months for male patients which is statistically significant (P=0,001). There is no significant difference in survival due to melanom primary site (P=0,32). The mean survival time for head-neck malign melanoma is 69.6 months, 114.1 months for body involvement and 82.0 months for extremity involvement.
DISCUSSION AND CONCLUSION: Malign melanoma has the worst progress in all skin cancers and there are several factors affecting the prognosis. The most important prognostic factors detected in this study are breslow thickness, primary tumor site and sex.

Malign Melanomlu hastalarýn klinikopatolojik incelenmesi

GÝRÝÞ ve AMAÇ: Bu çalýþmada Malign Melanom tanýlý hastalarýn Klinikopatolojik özelliklerini incelemeyi amaçladýk.
YÖNTEM ve GEREÇLER: Bu çalýþmada Dokuz Eylül Üniversitesi Hastanesi Týbbi Onkoloji bölümünde 1991-2011 Yýllarý arasýnda takip edilen malign melanom tanýlý 166 hasta retrospektif olarak deðerlendirilmiþtir.
BULGULAR: Hastalardan 87’si erkek, 79’u kadýndýr. Tüm hastalarýn ortanca yaþý 52 (21-81) dir. En sýk extremite bölgesinde malign melanom görülürken daha az sýklýkta baþ boyun ve gövdede gözlenmiþtir. Primer tümör bölgesi ile breslow kalýnlýðý arasýnda istatistiksel bir anlamlýlýk saptanmamýþtýr(p=0.109). Ancak breslow kalýnlýðý ile sað kalým arasýnda istatistiksel bir fark bulunmuþtur. Breslow kalýnlýðý 0-2 mm arasýnda olanlarýn ortalama saðkalýmý 125,6 ay(99-151), 2-4 mm arasýnda olanlarýn ortalama saðkalýmý 121,2 ay(92-151), 4 mm ve üstünde olanlarýn ortalama saðkalýmý 89 ay(68-111) olarak saptanmýþtýr ve aradaki fark istatistiksel olarak anlamlý saptanmýþtýr(p=0,012). Tüm hastalarýn 1 yýllýk saðkalým oraný %96, iki yýllýk saðkalým oraný %92.1 ve 5 yýllýk saðkalým oraný %82.7 saptanýrken; ortalama saðkalým süresi 89,74±6,9 ay olarak saptanmýþtýr. Kadýn cinsiyette ortalama saðkalým 108.8 ay, erkeklerde ortalama saðkalým 72.7 ay saptanmýþ olup aradaki fark istatistiksel olarak anlamlý bulunmuþtur(P=0,001). Melanomun primer yerleþim yerine göre saðkalýmlarý sýrasýyla baþ-boyun yerleþiminde 69.6 ay, gövde 114.1 ay, extremite yerleþiminde 82.0 ay olup aradaki fark istatistiksel olarak anlamlý saptanmamýþtýr(P=0,32).
TARTIÞMA ve SONUÇ: Malign melanom en kötü seyirli deri tümörü olup prognozu etkileyen faktörler birden fazladýr. Bu çalýþmada en önemli prognostik faktörler breslow kalýnlýðý, primer tümör yerleþim bölgesi ve cinsiyet olarak saptanmýþtýr.