Hand foot syndrome associated with docetaxel treatment in metastatic prostate cancer: A case report

Prostate cancer is one of the most common tumors in men. Docetaxel and prednisone treatment are accepted as standard chemotherapy in prostate cancer patients. Docetaxel is a chemotherapeutic drug of the taxane group that inhibits the depolymerization of tubulin and has an antitumoral effect through the stabilization of microtubules. It has also been reported that docetaxel therapy lead to cutaneous side effects besides systemic side effects. The most common cutaneous side effects of docetaxel are alopecia, hand foot syndrome, fixed plaque erythrodysesthesia, nail changes. Hand foot syndrome can be confronted with clinical tables ranging from bilateral, symmetrical erythema to desquamated plaques on hands and feet. It has been reported that hand foot syndrome occurred in the following weeks or months of chemotherapy treatment. We would like to present our case of hand foot syndrome associated with docetaxel chemotherapy treatment which is commonly used in patients with metastatic prostate cancer.

Dosetaksel tedavisi ile iliþkili El Ayak Sendromu geliþen metastatik prostat kanserli bir hasta

Prostat kanseri erkeklerde en yaygýn görülen tümörlerden biridir. Dosetaksel ve prednison tedavisi prostat kanserli hastalarda standart kemoterapi tedavisi olarak kabul edilmektedir. Dosetaksel tübülin depolimerizasyonunu engelleyerek, mikrotübüllerin stabilizasyonu yoluyla antitümöral etki gösteren taksan grubu kemoterapötik ilaçtýr. Dosetaksel tedavisinin sistemik yan etkilerinin yanýnda kutanöz yan etkilere yol açtýðý da bildirilmiþtir. Dosetaksel kullanýmý ile en sýk görülen kutanöz yan etkiler alopesi, el ayak sendromu, fiks plak eritrodizestezisi, týrnak deðiþiklikleridir. El ayak sendromu el ve ayaklarda bilateral, simetrik yerleþim gösteren eritemden, deskuamasyon gösteren ödemli plaklara kadar deðiþen klinik tablolarla karþýmýza çýkabilir. El ayak sendromu kemoterapi tedavisinin ilerleyen hafta veya aylarýnda ortaya çýktýðý bildirilmiþtir. Biz metastatik prostat kanserli hastalarda sýk kullanýlan dosetaksel kemoterapi tedavisi ile iliþkili el ayak sendromu geliþen olgumuzu sunduk.