Adenoid Cystic Carcinoma of the Breast: A Rare Histopathology- Good Prognosis

Background:
Adenoid cystic carcinoma (ACC), one of the rarest neoplasia of the breast, constitutes 0.1% of all breast carcinomas. The prognosis of ACC is very good compared to other histological subtypes of breast carcinoma. Lymph node involvement and distant metastasis are very infrequent. Estrogen receptor (ER), progesterone receptor (PR) and c-erbB2 (also known as HER-2/neu) are typically negative.

Case
A fourty eight year-old premenauposal women was admitted to hospital with a mass on the upper outer quadrant of her left breast. Since the result of through-cut biopsy of this suspicious lesion was consistent with adenoid cystic carcinoma, modified radical mastectomy with axillary lymph node excision was applied. Pathological examination revealed a moderately differantiated adenoid cystic carcinoma of the breast. The size of invasive tumor component was 4.8 cm in its greatest dimension. Immunohistochemical analysis was consistent with triple negative phenotype ( ER,PR and c-erbB2 negative).

Conclusion:
ACC is a rare type of human breast carcinoma with ER, PR and c-erbB2 negative phenotype. They usually show an excellent prognosis however there is no well defined treatment options for ACC since the rarity of clinical studies in such kind of unusual histological subtypes of breast carcinomas.

Meme Adenoid Kistik Karsinomlu Olgu: Nadir Histopatoloji- Ýyi Prognoz

Giriþ:

Adenoid kistik karsinom (ACC), memenin nadir görülen neoplazmlarýndandýr. Tüm meme karsinomlarýnýn %0.1’ini oluþturmaktadýr.
Adenoid kistik karsinomlar memede izlenen diðer histolojik alt tiplerine göre çok iyi prognoza sahiptirler.Uzak metastaz ve lenf nodu tutulumu çok nadirdir. Sýklýkla östrojen reseptörü (ER), progesteron reptörü(PR) ve cerbB2 statusu negatif olarak tespit edilmektedir.

Olgu:

Kýrksekiz yaþýnda premenapozal kadýn hasta sol memede ele gelen kitle nedeniyle doktora baþvurmuþ.
Hastaya memedeki lezyon için through-cut biyopsi uygulandý. Biyopsi sonucunun adenoid kistik karsinom olarak gelmesi üzerine hastaya modifiye radikal mastektomi operasyonu uygulandý. Operasyon materyalinin patolojik incelemesi orta derecede diferansiye adenoid kistik karsinoma ile uyumlu olarak tespit edildi. Tümör boyutu 4.8 cm ve aksiller diseksiyon sonucu 48 lenf nodu negatif olarak tespit edildi. Tümörün immünohistokimyasal özellikleri triple negatif (ER, PR ve c-erbB2) olarak deðerlendirildi.

Sonuç:
ACC’ler çoðunlukla ER(-),PR (-) ve CERBB2(-) hormon statusu ile ender görülen meme karsinomlarýdýr.
ACC’ler nadir görülen meme karsinomlarý olduðundan ve yeterli klinik çalýþma bulunmadýðýndan tedavi opsiyonlarý sýnýrlýdýr.