The Clinicopathological Characteristics of Stage I Granulosa Cell Ovarian Cancer

INTRODUCTION: We aimed to evaluate the clinicopathological characteristics of patients with stage 1 granulosa cell ovarian carcinoma (GCOC).
METHODS: Between July 2006 – December 2015, the clinical and pathological parameters, treatment features and long term follow up outcomes of 15 patients with stage 1 GCOC were evaluated retrospectively.
RESULTS: : Median age was 52 (24-71).According to FIGO staging system, 9 patients had stage 1A disease and 6 patientshad stage IC GCOC. Half of (53.3%) of the patients presented with uterine bleeding (53.3%) and left over (73.3%) was the most common localization. Ten patients had abdominal hysterectomy-bilateral salphingoopherectomy-pelvic paraaortic lymph node dissection-omentectomy and whereas 3 patients had total abdominal hysterectomy-bilateral salphingoopherectomy and 2 patients had fertility sparing surgery as a surgical procedure. 3 patients had perineural invasion, 2 patients had lymphovascular invasion.Histopathological evaluation of endometrium revealed simple hyperplasia without atypia in 6 patients. As adjuvant setting, 7 patients received 3 cycles of chemotherapy [bleomycin +etoposid+ cisplatin (BEP)]. Median follow up was 77.9 months (4.1 max=18.5 month) and median overall survival was 77.9 ay (95% CI, 39.6-116.3). None of the patients relapsed durring follow-up.
DISCUSSION AND CONCLUSION: Over granulosa cell carcinoma is rare. Randomized prospective clinical trials are needed to find out the high risk group for adjuvant chemotherapy.

Evre I Over Granüloza Hücre Kanserli Hastalarýn Klinikopatolojik Özellikleri

GÝRÝÞ ve AMAÇ: Bu çalýþmada kliniðimizdeki evre 1 over granüloza hücreli tümör (GHT) hastalarýn klinik verileri eþliðinde tedavi ve takip uygulamalarý ile bunlarýn sonuçlarý tartýþýlmýþtýr.
YÖNTEM ve GEREÇLER: Temmuz 2006 - Aralýk 2015 yýllarý arasýnda kliniðimizde evre 1 GHT tanýsý alan 15 hasta klinikopatolojik özellikleri, uygulanan tedaviler ve uzun süreli takip sonuçlarý açýsýndan deðerlendirilmiþtir.
BULGULAR: Medyan yaþý 52 (24-71) idi. FIGO Evreleme Sistemine göre 9 hasta evre IA iken 6 hasta evre IC idi. Hastalarýn yarýsý (53.3%) uterin kanama ile baþvurdu. En sýk (73.3%) yerleþim yeri ise sol over idi. Cerrahi tedavi olarak 10 hastaya total abdominal histerektomi+ bilateral salpingooferektomi+bilateral pelvik-paraaortik lenf nodu diseksiyonu+omentektomi, 2 hastaya sadece total abdominal histerektomi+bilateral salpingooferektomi ve 3 hastaya ise fertilite koruyucu cerrahi uygulanmýþtý. 3 hastada perinöral invazyon (PNI) ve 2 hastada lenfovasküler invazyon (LVI) saptandý. Endometrium histopatolojik deðerlendirilmesinde, 6 hasta ile en fazla basit atipisiz hiperplazi saptandý. Toplam yedi hastaya adjuvan tedavi olarak 3 kür [Bleomisin, Etoposid, Sisplatin (BEP)] kemoterapi rejimi verildi. Medyan takip süresi 77.9 ay (4.1-108.5 ay) ve genel saðkalým 77.9 ay (95% CI, 39.6-116.3)idi. Takiplerde hiçbir hastada nüks geliþmedi.
TARTIÞMA ve SONUÇ: Over GHT nadir görülmektedir. Erken evre hastalarda adjuvan tedavi uygulanacak hastalarý belirlemek üzere yüksek riskli grubunu saptamak için randomize çok merkezli prospektif çalýþmalara ihtiyaç vardýr.