Acta Oncol Tur.. 2019; 52(1): 169-176 | DOI: 10.5505/aot.2019.47568

Evaluation of the Response to Radiotherapy With Positron Emission Tomography/Computer Tomography in Head and Neck Carcinoma

Esra Kekilli¹, Candaþ Tunalý^2
1Dr Abdurrahman Yurtaslan Ankara Oncology Training And Research Hospital, Ankara
²Çukurova University Faculty Of Medicine. Radiation Oncology, Adana

INTRODUCTION: The aim of this study is to assessment of therapy response to radiotherapy or concurrent chemoradiotherapy in patients with head and neck carcinoma using with Positron Emission Tomography/Computer Tomography.

METHODS: 36 head and neck cancer patients who were treated in our clinic between April 2009 and April 2011 were prospectively included this study. All patients were scanned with Positron Emission Tomography/Computer Tomography imaging before and after treatment and therapy response was evaluated by using standard uptake value max. Positron Emission Tomography/Computer Tomography results and biopsy that was taken from primary tumor as histopatologic assessing used for patients staging. This staging is based on American Joint Committee on Cancer 6.th edition.

RESULTS: Patients who were accepted this study were 32 male (88,9 %) and 4 female (11,1 %). The mean age of the patients was 57,5 (35-77) years. Mean follow up time was 13,5 months. Pretreatment mean of standard uptake value max was 11. High standard uptake values max (>11) predicted significantly worse treatment response as compared with low standard uptake value max (<11). Standard uptake value max was increased as the stage increased. At the end of the treatment standard uptake value max in early stage patients (0,002) was much more regressed than advanced stage patients (<0,001).

DISCUSSION AND CONCLUSION: In this study demonstrated that the patients with pretreatment high standard uptake value max had poorer treatment response. This study showed that pretreatment and the difference standard uptake values max are strong related with therapy response.

Keywords: Head and neck cancer, Positron Emission Tomography/Computer Tomography, standard uptake value, therapy response.

---

Baþ Boyun Kanserlerinde Radyoterapi Sonrasýnda Tedavi Etkinliðinin Pozitron Emisyon Tomografi/Bilgisayarlý Tomografi Ýle Deðerlendirilmesi

Esra Kekilli¹, Candaþ Tunalý^2
1Dr Abdurrahman Yurtaslan Ankara Onkoloji Eðitim Ve Araþtýrma Hastanesi, Ankara
²Çukurova Üniversitesi Týp Fakültesi, Radyasyon Onkolojisi Anabilim Dalý, Adana

GÝRÝÞ ve AMAÇ: Bu çalýþmanýn amacý baþ boyun kanserli hastalarda radyoterapi ya da eþzamanlý kemoradyoterapi sonrasý tedavi cevabýnýn Pozitron EmisyonTomografi/Bilgisayarlý Tomografi ile deðerlendirilmesidir.

YÖNTEM ve GEREÇLER: Nisan 2009 ile Nisan 2011 tarihleri arasýnda, kliniðimizde tedavi edilmiþ baþ boyun kanserli 36 hasta prospektif olarak çalýþmaya dahil edilmiþtir. Tüm hastalara tedavi öncesinde ve sonrasýnda Pozitron Emisyon Tomografi/Bilgisayarlý Tomografi görüntüleme yapýlmýþtýr ve bu görüntülemede elde edilen maksimum standart tutulum deðerleri incelenerek tedaviye yanýt deðerlendirilmiþtir. Hastalýk evrelemesi yapýlýrken primer tümörden alýnan biyopsilerin histopatolojik incelenmesi ve Pozitron Emisyon Tomografi/Bilgisayarlý Tomografi esas alýnmýþtýr. Tümörlerin evrelemesi American Joint Committee on Cancer 6. baskýya göre yapýlmýþtýr.

BULGULAR: Çalýþmaya alýnan 36 hastanýn 32’si erkek (% 88,9), 4’ü kadýn (% 11,1)’dýr. Yaþ ortalamasý ise 57,5 (35-77) olarak saptanmýþtýr. Olgularýmýzýn ortalama takip süresi 13,5 aydýr. Hastalarýn tedavi öncesi Pozitron Emisyon Tomografi/Bilgisayarlý Tomografi ile ölçülen maksimum standart tutulum deðerlerinin ortalamasý 11 (3,5-23)’dir. Maksimum standart tutulum deðeri 11’den büyük hastalarýn
tedavi yanýtlarý küçük olan hastalara göre daha kötü bulunmuþtur. Evrenin artýþýyla standart tutulum deðerinin arttýðý ve standart tutulum deðerinin tedavi sonunda erken evre hastalarda (p=0,002), ileri evre hastalara kýyasla çok daha fazla gerilediði saptanmýþtýr (p<0,001).

TARTIÞMA ve SONUÇ: Bu çalýþmada tedavi öncesi maksimum standart tutulum deðeri yüksek hastalarýn tedavi yanýtlarýnýn daha kötü olduðu ayrýca tedavi öncesi standart tutulum deðerleri ve standart tutulum fark deðerleri ile tedavi yanýtý arasýnda güçlü bir iliþkinin olduðu gösterilmiþtir.

Anahtar Kelimeler: Baþ boyun kanserleri, Pozitron Emisyon Tomografi/Bilgisayarlý Tomografi, standart tutulum deðeri, tedavi cevabý.

---