ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

INTRODUCTION: Aim: In this study we aimed to evaluate the alterations in hematological parameters due to the adjuvant chemotherapy treatment in patients with colorectal cancer.


METHODS: Material and Method: In a total of 140 cases diagnosed with colorectal cancer were evaluated and among those patients 57 received adjuvant chemotherapy. Alterations in complete blood count parameters after adjuvant chemotherapy were evaluated.
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RESULTS: Results: Among participants, 67 (47.9%) were women and 73 (52.1%) were men with a mean age of 62.13 ± 1.11 years. The most common tumor localization was rectum (45.7%). Among these patients 57 received adjuvant chemotherapy (40.7%), the most frequently implemented chemotherapy regimen was Mayo regimen (84.2%). 27.9% of our cases had metastasis at the time of diagnosis. During clinical follow-up 10.7% of the patients had local relapse and 7.8% had metastasis. Hemoglobin (HGB) levels displayed a significant decrease both in patients who received blood transfusion or not, however this was more evident in the group of patients with no previous transfusion (p=0.002). Following the adjuvant chemotherapy, white blood cell values (WBC), mean erythrocyte volumes (MCV) and thrombocyte (PLT) levels were found to decrease significantly without any interaction with modifying components (metastasis development, chemotherapy implementation duration, blood transfusion) (p values 0.002, 0.001 and 0.001 respectively) while red cell distribution width (RDW) had increased significantly (p=0.001).

DISCUSSION AND CONCLUSION: Conclusion: There was a significant decrease in Hgb, MCV, WBC and platelet levels and a significant increase in RDW after adjuvant chemotherapy and these alterations were not affected by the presence of metastasis or duration of chemotherapy. The association of these alterations in blood parameters with the prognosis of patients should be investigated in further studies

Kolorektal Kanserli Hastalarda Adjuvan Kemoterapi Öncesi Ve Sonrasinda Hematolojik Parametrelerin Deðerlendirilmesi

GÝRÝÞ ve AMAÇ: Bu çalýþmada kolorektal kanserli hastalarda adjuvan kemoterapi tedavisi sonrasýnda hematolojik parametrelerdeki deðiþiklikleri deðerlendirmeyi amaçladýk.
YÖNTEM ve GEREÇLER: Kolorektal kanser tanýsý konan toplam 140 vakada deðerlendirilmiþ ve bu hastalardan 57'sine adjuvan kemoterapi verilmiþtir. Adjuvan kemoterapi sonrasý tam kan sayýmý parametrelerindeki deðiþiklikler deðerlendirildi.
BULGULAR: Katýlýmcýlarýn 67'si (% 47.9) kadýn, 73'ü (% 52.1) erkek idi, yaþ ortalamalarý 62.13 ± 1.11 yýl idi. En sýk görülen tümör yerleþimi rektumdu (% 45.7). Bu hastalardan 57'si adjuvan kemoterapi (% 40.7) aldý, en sýk uygulanan kemoterapi rejimi Mayo rejimi (% 84.2) idi. Olgularýmýzýn % 27.9'unda taný anýnda metastaz vardý. Klinik takip sýrasýnda hastalarýn% 10.7'sinde lokal nüks ve% 7.8'inde metastaz vardý. Hemoglobin (HGB) düzeyleri hem kan transfüzyonu yapýlan hastalarda hem de yapýlmayanlarda anlamlý bir düþüþ gösterdi, ancak bu daha önce transfüzyonu olmayan hasta grubunda daha belirgindi (p = 0.002). Yardýmcý kemoterapiyi takiben, beyaz kan hücresi deðerleri (WBC), ortalama eritrosit hacimleri (MCV) ve trombosit (PLT) seviyelerinin, modifiye edici bileþenlerle (metastaz geliþimi, kemoterapi uygulama süresi, kan transfüzyonu) herhangi bir etkileþim olmadan önemli ölçüde azaldýðý bulundu. (Sýrasýyla p deðerleri 0.002, 0.001 ve 0.001), ayrýca kýrmýzý hücre daðýlým geniþliði (RDW) önemli ölçüde artmýþtýr (p = 0.001).
TARTIÞMA ve SONUÇ: Hgb, MCV, WBC ve trombosit seviyelerinde anlamlý bir azalma ve adjuvan kemoterapi sonrasý RDW'de anlamlý bir artýþ vardý ve bu deðiþiklikler metastaz varlýðýndan veya kemoterapi süresinden etkilenmedi. Kan parametrelerinde bu deðiþikliklerin hastalarýn prognozu ile iliþkisi ileriki çalýþmalarda araþtýrýlmalýdýr.